BioCeuticals AntiOx Excel (60 capsules)

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BioCeuticals AntiOx Excel (60 capsules)

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  • Potent antioxidant formulated to minimise oxidative stress and reduce free radical-induced cellular damage and LDL oxidation.

  • Potent formula allows for convenient one-a-day dosing.

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Fallopia japonica – resveratrol
Giant knotweed (Fallopia japonica) has been used in traditional Chinese medicine. Only recently has it been found to be a rich source of resveratrol, which in vitro studies suggest is a potent antioxidant.

Under the microscope, resveratrol is active against reactive oxygen species (ROS) such as lipid hydroperoxyl, hydroxyl and superoxide anion radicals, and has been shown to induce the synthesis of glutathione (GSH), which plays a major role in cellular antioxidant defence.[1-3]

Vitis vinifera – proanthocyanidins
The seeds and skin of grapes (Vitis vinifera) are abundant in proanthocyanidins, a class of antioxidant plant constituents.

Grape seed is traditionally used in western herbal medicine for the symptomatic relief of cutaneous capillary fragility, swelling, heaviness and tingling in the legs.[4]

Silybum marianum (milk thistle)
Milk thistle has been extensively used in traditional western herbal medicine to support healthy liver and gallbladder function for more than 2000 years.

The primary active constituents of milk thistle seed are the flavanolignans collectively known as silymarin, of which the four major components are silybin (silybinin, silibinin), silychristin, silydianin and isosilybinin. Silybin makes up about 70% of silymarin.

When ingested, silymarin undergoes enterohepatic recirculation and has higher concentrations in liver cells. In the last 10 years, about 12,000 research papers have been published on these substances and their antioxidant and liver tonic effects, as an inhibitor of phase 1 detoxification and an enhancer of phase 2 glucuronidation.[5-8]

Glutathione (GSH)
GSH is often referred to as the ‘master antioxidant’, an accurate description given that it is the most abundant endogenous antioxidant and a key regulator of oxidative stress and immune function.[9]

Glutathione is involved in detoxification and elimination of metabolic by-products.

Setria® GSH is clinically proven to increase GSH levels and reduce biomarkers of oxidative stress.[9]

Selenium
Selenium is used in the synthesis of several antioxidant enzymes, including glutathione peroxidase, involved in supporting the health of various body tissues (including the heart, kidney, liver, skeletal muscle and sperm).

Vitamin C
Vitamin C is a highly effective antioxidant that also regenerates other antioxidants in the body, such as GSH, tocopherol and flavonoids. Vitamin C additionally plays a role in collagen production and healthy connective tissue integrity, as well as the immune system.

Riboflavin (vitamin B2) and nicotinamide (vitamin B3)
Both riboflavin and nicotinamide are involved in the regeneration of GSH, riboflavin as a precursor to FAD (flavin adenine dinucleotide) and nicotinamide as a precursor to NADPH (nicotinamide adenine dinucleotide phosphate). FAD and NAD are coenzymes for GSH reductase, which reduces oxidised glutathione to its active form.[10]

Alpha-lipoic acid
Alpha-lipoic acid is an important water and lipid soluble antioxidant, which has the ability to regenerate other endogenous antioxidants including GSH, vitamin C and vitamin E.[10]

Mixed tocopherols and tocotrienols (EVNolMax™)
EVNolMax™ provides a blend of all eight naturally occurring isomers (alpha, beta, gamma and delta tocotrienols and tocopherols) of vitamin E for maximum antioxidant activity.

A combination of tocopherols was found to be superior to individual tocopherols on markers of oxidative stress.[11]

  • Not recommended for pregnant or lactating women.
  • In vitro evidence suggests that Silybum marianum may theoretically elevate serum warfarin levels.[12]
  • Concomitant use of vitamin A with isotretinoin may increase toxicity. Avoid this combination.[12]
  • Increased vitamin A levels occur in oral contraceptive pill users due to longer storage in the liver. Use caution with large doses of retinol.[12]

[1] Hsu CY, Chan YP, Chang J. Antioxidant activity of extract from Polygonum cuspidatum. Biol Res 2007;40(1):13-21.
[2] Burns J, Yokota T, Ashihara H, et al. Plant foods and herbal sources of resveratrol. J Agric Food Chem 2002;50(11):3337-3340.
[3] Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 2005;49(5):472-481.
[4] Shi J, Yu J, Pohorly JE, et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 2003;6(4):291-299.
[5] Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol 2011;17(18):2288-2301.
[6] Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Invest 2002;22(1):51-65.
[7] Silybum marianum (milk thistle). Altern Med Rev 1999;4(4):272-274.
[8] Fraschini F, Demartini G, Esposti D. Pharacology of silymarin. Clin Drug Investig 2002;22(1):51-65.
[9] Richie JP Jr, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr 2015;54(2):251-263.
[10] Natural Medicine Comprehensive Database 2015, www.naturaldatabase.com
[11] Devaraj S, Leonard S, Traber MG, et al. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med 2008;44(6):1203-1208.
[12] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.