BioCeuticals GlucoFactors® Forte (60 capsules)

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BioCeuticals GlucoFactors® Forte (60 capsules) - supplement facts.JPG

BioCeuticals GlucoFactors® Forte (60 capsules)

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  • Features GLUTForce® herbal combination of bitter melon and goat's rue.

  • Involved in the metabolism of carbohydrates.

  • Chromium is important for diets high in carbohydrates and sugar.

  • Chromium is a fundamental component in healthy glucose utilisation and lipid metabolism.

  • Chromium is a key factor in normal healthy glucose metabolism by aiding glucose uptake into cells.

  • Alpha-lipoic acid provides nutritional support for healthy glucose metabolism and is a potent antioxidant and free radical scavenger.

  • Gymnema contains gurmarin, a polypeptide responsible for its sweetness-suppressing qualities.

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  • Healthy glucose metabolism
    With the increase and disproportional amount of simple carbohydrates in our modern western diets, the ability for the body’s insulin to handle the increased blood glucose has become a problem. With this change in diet comes the increased risk and incidence of a number of health conditions and deficiencies in nutrients such as chromium.[9-12] Diets high in simple sugars have been found to increase urinary chromium excretion up to 30-fold.[2]

    Momordica charantia (Bitter melon)
    Bitter melon has a long history of use in Asia, Africa and Latin America, and its mechanism of action has been attributed to the support of beta-cell integrity. [2,13,14]

    Gymnema sylvestre (Gymnema)
    Gymnema has a long tradition of use in Ayurvedic medicine, and its main active constituent is gymnemic acid, which is responsible for its sweetness-suppressing qualities.[1] GlucoFactors Forte® is standardised to no less than 50% gymnemic acids.

    Galega officinalis (Goat’s rue)
    Goat’s rue has been traditionally used in France to maintain normal healthy blood glucose levels.[15]

    Trigonella foenum-graecum (Fenugreek)
    Fenugreek has been used for thousands of years in Asian and Mediterranean cultures and in Ayurvedic medicine, and one of the active ingredients in fenugreek is an amino acid 4-hydroxyisoleucine, which is involved in pancreateic insulin secretion.[16]

    Alpha-lipoic acid
    Alpha-lipoic acid is a potent fat- and water-soluble antioxidant that provides nutritional support for glucose transport and metabolism. It assists in the metabolism of carbohydrates and is involved in the processes that convert food into energy.

    In vitro studies suggest that alpha lipoic acid provides antioxidant protection.[17,18]

    Biotin
    The B vitamin biotin is involved in the regulation of normal healthy carbohydrate metabolism.

    Chromium
    Chromium is involved in carbohydrate, fat and protein metabolism and is a fundamental component in healthy glucose utilisation and glycaemic control by aiding cellular glucose uptake.

    People with high intake of dietary sugar and refined carbohydrates have an increased requirement for chromium.

    Both picolinate and chloride forms are supported in clinical trials,[14] and using a mix maximises availability and allows for higher dosages.

    Chromium's mechanism of action[4]

    1. Initially, in response to an increase in blood sugar, insulin is released into the blood, stimulating the transport of transferrin-bound chromium to insulin-sensitive cells.

    2. Insulin binds to the insulin receptor on the insulin-sensitive cell.

    3. The insulin receptor is now activated and stimulates the movement of chromium into the cell.

    4. In the cell, chromium binds to the protein apo-LC (apo-chromodulin or ApoLMWCr).

    5. The binding of four chromium molecules to apo-LC creates a complex called chromodulin (LC). LC is a low molecular weight chromium binding substance.

    6. LC binds to the insulin receptor and enhances the protein kinase (tyrosine-kinase) activity of the receptor. This promotes the various phosphate addition reactions (phosphorylation) involved in glucose utilisation, protein synthesis and lipid metabolism. The ability of LC to activate the insulin receptor is dependent on its chromium content.

  • GlucoFactors Forte® is contraindicated in pregnancy. Chromium appears to be safe in pregnancy and lactation however bitter melon is contraindicated, and Trigonella foenum-graecum has empirical use as an emmenagogue and abortifacient.[1,2,3]
  • The use of Gymnema sylvestre and alpha-lipoic acid in lactation has not been scientifically validated.
  • Chromium and iron compete for binding sites on transferrin, the iron transport protein. However, doses up to 925mcg of chromium per day have shown no significant effect on iron status.[4]
  • One single case report suggests a theoretical interaction between the concomitant use of chromium with insulin in which hypoglycaemia was provoked.[5]
  • Caution G. sylvestre with concomitant use of antidiabetic medications. Gymnema has reduced blood glucose in diabetic patients, thereby requiring dosage adjustments of diabetic medication.[3]
  • Caution with hypoglycaemic agents; theoretically an additive effect is possible.[2]
  • Theoretically, concomitant use of goat's rue could potentiate hypoglycaemic drug effects.[6]
  • Some literature caution that using alpha-lipoic acid with antidiabetic drugs may theoretically cause additive hypoglycaemic effects. However, two randomised, controlled studies show no detectable drug interaction or safety issues with the concomitant intake of alpha-lipoic acid (up to 600mg daily) with glibenclamide, acarbose (Glucobay), metformin, sulfonylureas, troglitazone or insulin.[7,8]
  • [1] Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67(6):1250-1255.
    [2] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.
    [3] Brinker F. Herb contraindications and drug interactions, 3rd ed. Oregon: Eclectic Medical Publications, 2001.
    [4] Higdon J. An evidence-based approach to vitamins and minerals. New York: Thieme Medical Publishers, 2003.
    [5] Bunner SP, McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299.
    [6] Goat's rue. Natural Medicines Comprehensive Database. Viewed 9 May 2013 http://www.naturaldatabase.com
    [7] Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999 Dec;48(6):819-825.
    [8] Evans JL, Heymann CJ, Goldfine ID, et al. Pharmacokinetics, tolerability and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr Pract 2002;8(1):29-35.
    [9] Metabolic syndrome. Nutrition Australia. Viewed 15 May 2013, http://www.nutritionaustralia.org/national/frequently-asked-questions/diabetes/metabolic-syndrome
    [10] Diabetes type 2. InteliHealth. Viewed 15 May 2013, http://www.intelihealth.com/IH/ihtIH/WSIHW000/35072/35073/360341.html?d=dmtContent
    [11] High blood glucose: What it means and how to treat it. Joslin Diabetes Center. Viewed 15 May 2013, http://www.joslin.org/info/high_blood_glucose_what_it_means_and_how_to_treat_it.html
    [12] Metabolic syndrome. Better Healthy Channel. Viewed 25 May 2013, http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Metabolic_syndrome
    [13] Ahmed I, Adhghate E, Cummings E, et al. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem 2004;261(1-2):63-70.
    [14] Yeh GY, Eisenberg DM, Kaptchuk TJ, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26:1277-1294.
    [15] Goat's rue (Galega officinalis). Natural Standard. Viewed 15 May 2013, www.naturalstandard.com
    [16] Sauvaire Y, Petit P, Broca C, et al. 4-hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 1998;47:206-210.
    [17] Wang Y, Dong W, Wang F, et al. Protective effect of α-lipoic acid on islet cells co-cultured with 3T3L1 adipocytes. Experimental Therapeut Med 2012;4(3):469-474.
    [18] Goldbidi S, Badran M, Laher I. Diabetes and alpha lipoic acid. Frontiers in Pharmacol 2011;2:69.