BioCeuticals Inflam-Eze Activ (60 tablets)

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BioCeuticals Inflam-Eze Activ (60 tablets)

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InflamEze Activ combines the properties of devil’s claw (Harpogophytum procumbens), cat’s claw (Uncaria tomentosa) and curcumin from turmeric (Curcuma longa) with the antioxidant properties of green tea (Camellia sinensis), to help regulate painful and inflammatory symptoms.

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Harpagophytum procumbens(Devil's claw)
Harpagosides from H. procumbens downregulate the activation of NFkB, which controls the expression of a wide range of pro-inflammatory signals including tumour necrosis factor-α (TNF-α), COX-2 and inducible nitrogen oxide synthase (iNOS). The end result is a generalised anti-inflammatory effect which may explain the positive effects of H. procumbens in rheumatic and arthritic conditions.[7]

Uncaria tomentosa(Cat's claw)
U. tomentosa has also been shown to downregulate the activation of NFkB and reduce the expression of iNOS, an inflammatory mediator released in response to oxidant-induced stress.[8]

Furthermore, U. tomentosa exerts antioxidant activity via its proanthocyanidins, with data indicating that it is an effective neutraliser of superoxide anions, hydroxyl radicals, hydrogen peroxide and hypochlorous acid.[9]

Camellia sinensis(Green tea)
Camellia sinensis (green tea) polyphenols are potent antioxidants.[10]

Curcuma longa(Curcumin)
Curcumin exhibits inhibitory activity at a number of sites along the arachidonic acid inflammatory cascade, including inhibition of phospholipase A2 and phospholipase Cy1, which results in the reduction of arachidonic acid release from cellular phospholipids.[11]

Activation pathway for NFkB:

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  • Uncaria tomentosa is not recommended in preconception care, pregnancy or lactation due to the traditional use of cat’s claw as a contraceptive.[1]
  • Due to its immunostimulating properties, there is concern that U. tomentosa may adversely affect patients with autoimmune disorders.[2]
  • Harpagophytum procumbens may reduce blood glucose levels; caution with co-administration of diabetic medication.[3]
  • Rare case reports suggest H. procumbens may potentiate the effects of warfarin, unsupported by clinical evidence.[4]
  • Caution with antiplatelet/anticoagulant medications. Concomitant use of curcumin with antiplatelet/anticoagulant medications may theoretically increase the risk of bleeding, and catechins in green tea are reported to have antiplatelet activity.[4-6]
  • Use with caution in patients taking antihypertensive medication as H. procumbens and U. tomentosa may lower blood pressure.[2,3]
  • Theoretically, U. tomentosa may interfere with immunosuppressant thearpy due to its immunostimulating activity.[2]