BioCeuticals Intestamine® (150g)

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BioCeuticals Intestamine® (150g)

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Intestamine® contains key herbs and nutrients that provide support for the function of a healthy digestive tract, and to help soothe gastrointestinal (GI) function. This vegan-friendly, shellfish-free blend, now with Chios Mastiha Mastic gum, helps to nourish and soothe an inflamed and irritated GI mucosa.

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Recommended Dosage:  Mix 5 g dose (1 level metric teaspoon) into 100-200mL of water or juice.  Consume once or twice daily, or as directed by your healthcare practitioner. 

Dyspepsia

Those who experience dyspepsia, commonly known as indigestion, may have typical symptoms which include postprandial (after eating) fullness, early satiation (fullness), and epigastric pain and burning. Other upper GI symptoms such as nausea, belching or abdominal bloating can often occur.[1]

Pistacia lentiscus (Chios Mastiha Mastic)

Mastic gum has been used in traditional Greek medicine for over 2500 years for the relief of dyspepsia and mild stomach pain.[2] Many ancient Greek authors, including Dioscorides (the father of pharmacology) and Theophrastus, mention Chios mastic for its healing properties in the intestines, stomach and liver.[3]

Chios Mastiha Mastic belongs to the Pistacia lentiscus species, an evergreen shrub extensively spread through the Mediterranean region. P. lentiscus cv. Chia is exclusively cultivated with care and sustainable practices, in southern Chios (Mastichochoria), a Greek island.[4] Chios Mastiha Mastic is the high quality, natural and aromatic resinous excretion of the mastiha tree. This unique resin consists of an excellent variety of therapeutic and aromatic ingredients, such as terpenic acids (masticadienonic and isomasticadienonic acid), mastic oil, phytosterols, volatile ingredients, polyphenolic molecules, that constitute the essential oil, and a large number of other ingredients. This combination of more than 80 ingredients justifies the multiple uses of Chios Mastiha Mastic, in the food, health and personal care sectors.[5]

Chios Mastiha Mastic has Protected Designation of Origin (PDO) and Protected Geographical Indication (PGI) status in the European Union (EU), highlighting the unique quality, authenticity and traceability of this plant material.[6] In 2015, Chios Mastiha Mastic was assigned an EU herbal monograph of its own by the European Medicines Agency (EMA), as a traditional herbal medicine used in mild dyspeptic disorders.[4]

Theracurmin

Curcumin, the chief active constituent of turmeric (Curcuma longa), has demonstrated antioxidant activity and also helps to support healthy digestive system function and gallbladder contraction (flow of bile).[7-9] It is well known that gastrointestinal absorption of curcumin is poor. Patented manufacturing techniques have overcome this problem with Theracurmin, shown to have superior solubility and more rapid absorption due to the colloidal dispersion of curcumin. It reaches peak plasma levels within one hour of ingestion, and continues to be detected at significantly higher concentrations in plasma at 24 hours following a single dose. This is an indication that absorption may in fact occur extraintestinally.[8,10]

Theracurmin features a reduced particle size of curcumin suspended in a natural matrix, dramatically increasing its solubility and absorption. Particle size is 0.19mcm, whereas regular curcumin is 22.75mcm.[10]

Ulmus rubra (slippery elm)

Slippery elm has long been used in traditional western medicine for its demulcent effect on the GI tract.[11] The inner bark of slippery elm chiefly contains mucilage, which coats the surface of the mucous membranes with a gel-like layer, and may also exert mild local anti-inflammatory activity.[11] Based on traditional western herbal medicine usage as a soothing demulcent, slippery elm can help relieve symptoms associated with medically diagnosed mild gastritis and dyspepsia.[11]

  • This product is not recommended for use in pregnancy or lactation.
  • Due to the antiplatelet activity of curcumin, suspend use one week prior to major surgery.[11]
  • Curcumin can cause gallbladder contractions and should not be used by individuals with gallstones or bile duct obstruction.[9]
  • Glutamine is contraindicated in patients with hepatic disease and should only be used under professional supervision in people with chronic renal failure.[11]
  • Slippery elm (mucilage) forms an inert barrier over the intestinal lining and may theoretically alter the rate and/or extent of absorption of medicines with narrow therapeutic indexes (such as barbiturates, digoxin, lithium, phenytoin and warfarin). It is advisable to separate doses by at least two hours.[11]
  • Pectin may interfere with the intestinal absorption of digoxin, lovastatin and tetracyclines.[12]
  • Aloe vera may have hypoglycaemic activity, therefore additive effects are theoretically possible when taken in conjunction with hypoglycaemic agents.[11]
  • Glutamine is a precursor of the excitatory neurotransmitter glutamate and, therefore, may theoretically antagonise the anticonvulsant effects of medications taken for epilepsy.[11]

[1] Tack J, Talley NJ. Functional dyspepsia - symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol 2013;10(3):134-141
[2] Bozorgi M, Memariani Z, Mobli M, et al. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. Lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. Sci World J 2013;2013:219815.
[3] Kaliora AC, Stathopoulou MG, Triantafillidis JK, et al. Chios mastic treatment of patients with active Crohn’s disease. World J Gastroenterol 2007;13(5):748-753.
[4] Overview of the major scientific publications on the beneficial activity of Chios Mastiha: extended version. The Chios Mastiha growers association, 2015. Viewed 20 Sep 2017, http://www.gummastic.gr/public/Leaflets/Scientific_Publicatons_of_the_beneficial_properties_of_Mastiha_Jan_2016.pdf
[5] Chios Mastiha medical and scientific reports. The Chios Mastiha growers association. Viewed 20 Sep 2017, http://www.mastihashopny.com/files/File/PDF/medical&scireports.pdf?
[6] The Chios Mastiha growers association. Viewed 20 Sep 2017, https://www.gummastic.gr/en/?
[7] Rasyid A, Rahman AR, Jaalam K, et al. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr 2002;11(4):314-318.?
[8] Shimatsu A, Kakeya H, Imaizumi A, et al. Clinical application of “curcumin”, a multi-functional substance. Anti-Aging Medicine 2012;9(1):45-51.
[?9] Natural Medicine Comprehensive Database 2017. Viewed 19 Sep 2017, www.naturaldatabase.com?
[10] Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 2011;34(5):660-665.?
[11] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.?
[12] Hendler SS, Rorvik DM (Eds). PDR® (Physicians’ Desk Reference) for nutritional supplements, 2nd ed. Montvale: Thomson Reuters, 2008.