BioCeuticals Paracea® Forte (60 capsules)

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BioCeuticals Paracea® Forte (60 capsules)

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  • Upgraded formula now contains standardised herbal extract constituents including artemisinin (Chinese wormwood), berberine (barberry), gingerols (ginger), and clove.

  • Vegan friendly formula.

  • Enteric coated tablet bypasses acidity of the stomach, for targeted intestinal delivery.

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Parasites

Parasites are organisms that live inside another organism (the host), harming the host. Parasites that infect people include protozoa (such as amoebas) which consist of only one cell, and worms (helminths, such as hookworms and tapeworms) which are larger, consist of many cells and have internal organs.[1]

Artemisia annua (Chinese wormwood)

Chinese wormwood, and its major active constituent artemisinin, have been shown to provide antimalarial and antimicrobial activity in animal and in vitro studies.[2] These studies support Chinese wormwood’s traditional use in TCM for malaria, and as an antimalarial.[3] It has also been used in TCM for its anthelmintic activity; the ability to rid the body of worms.[3] Chinese wormwood has been shown in vitro to strongly inhibit the growth of the parasitic protozoa Naegleria fowleri.[4]

Berberis vulgaris (barberry)

Barberry is an important source of berberine, an isoquinoline alkaloid, and has a long history of use in both Ayurvedic and Chinese medicine.[5] Berberine has demonstrated antimicrobial activity against a wide range of bacteria, viruses, fungi, protozoans and helminths in vitro.[6] This supports barberry’s traditional use for diarrhoea and symptomatic relief of microbial overgrowth.[6] Berberine has been shown to inhibit the growth of intestinal parasites including Trichomonas vaginalis, Giardia lamblia and Leishmania donovani, by multiple mechanisms in animal and in vitro studies.[6,7] In vitro studies also demonstrated berberine was rapidly amoebicidal and caused encystation, degeneration, and eventual lysis of the trophozoite forms of the parasite Entamoeba histolytica.[8] Berberine has also been shown in vitro to reduce diarrhoea-causing bacteria such as Escherichia coli, Vibrio cholerae, Shigella dysenteriae, Salmonella paratyphi, Clostridium perfringens and Bacillus subtilis.[5,6]

Juglans nigra (black walnut)

Black walnut hull is used traditionally as an anthelmintic, and may also have a normalising and tonifying effect on intestinal tissue.[9] 

Zingiber officinale (ginger)

Ginger root is an important digestive herb which can assist to reduce symptoms of nausea, and is used in traditional WHM to relieve GIT discomfort and painful digestion, which may be present during parasitic infections or treatment.[3] It may also stimulate gastric motility (emptying), and support digestion.[10] In vitro and animal studies show that ginger also possess antimicrobial activity against various bacteria including Staphylococcus aureus, Streptococcus pyrogenes, S. pneumonia and parasites.[5]

Clove

Clove has demonstrated antibacterial, antiviral and anti-parasitic activity against a range of micro-organisms according to in vitro research.[5] In vitro evidence suggests that the antimicrobial activity of clove is attributable to eugenol, oleic acids and lipids found in its volatile oil.[11]

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  • Paracea® Forte is not recommended for use during pregnancy; barberry is contraindicated in pregnancy and Chinese wormwood is not recommended in pregnancy or lactation.[12]
  • Not recommended for prolonged use.
  • Theoretically, ginger may have an antiplatelet effect; use with caution with warfarin.[5]
  • Clove is reported to have antiplatelet activity in vitro. Be cautious of use with anticoagulant/ antiplatelet medications.[13]
  • Grapefruit juice is known to affect the metabolism of several medications [14]. Paracea® Forte contains an extract of grapefruit. The flavonoid narigenin is the component of grapefruit juice known to have been associated with an effect on these medications. The narigenin content of the grapefruit extract in Paracea® Forte is 0.1%, and at these levels, there is not likely to be a significant impact on the metabolism of these medications.

[1] Porter RS, Kaplan JL. The Merck Manual of Diagnosis and Therapy, 18th ed. Whitehouse Station, NJ: Merck Sharp & Dohme Corp, 2011.
[2] Bone K. Clinical applications of Ayurvedic and Chinese herbs. Warwick: Phytotherapy Press, 1996.
[3] WHO Monographs on selected medicinal plants, vol 1-4. Viewed 4 July 2017, http://apps.who.int/medicinedocs/en/d/Js2200e/
[4] Mendiola J, Bosa M, Perez N, et al. Extracts of Artemisia abrotanum and Artemisia absinthiuminhibit growth of Naegleria fowleri in vitro. Trans R Soc Trop Med Hyg 1991;85(1): 78-79.
[5] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.
[6] Berberine. Altern Med Rev 2000;5(2):175-177.
[7] European barberry. Natural Medicines Comprehensive Database 2015. Viewed 28 Jun 2017, www.naturalmedicines.therapeuticresearch.com
[8] Subbaiah TV, Amin AH. Effect of berberine sulphate on Entamoeba histolytica. Nature 1967;215(5100):527-528.
[9] Black walnut. Natural Medicines Comprehensive Database 2015. Viewed 29 Jun 2017, www.naturalmedicines.therapeuticresearch.com
[10] Hu ML, Rayner CK, Wu KL, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol 2011;17(1):105-110.
[11] Nzeako BC, Al-Kharousi ZSN, Al-Mahrooqui Z. Antimicrobial activities of clove and thyme extracts. SQUMJ 2006;6(1):33-39.
[12] Brinker F. Herb contraindications and drug interactions 3rd ed. Sandy: Eclectic Medical Publications, 2001.
[13] Clove. Natural Medicines Comprehensive Database 2016. Viewed 4 July 2017, www.naturaldatabase.com
[14] Grapefruit. Natural Medicines Comprehensive Database 2016. Viewed 4 July 2017, www.naturaldatabase.com