BioCeuticals Ultra Biotic Urinary Care (30 vegetarian capsules)

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BioCeuticals Ultra Biotic Urinary Care - supplement facts.JPG

BioCeuticals Ultra Biotic Urinary Care (30 vegetarian capsules)

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An evidence-based formula to help combat unfriendly bacteria and promote a healthy urinary tract.

Modified release capsules, to ensure the pomegranate and lactobacilli reach the lower intestinal tract where ellagic acid is metabolised at greater efficacy.

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Cranberry (Vaccinium macrocarpon)
About 25% of women experience recurrent urinary tract infections (UTIs), with almost 95% being caused by E. coli.[1] UltraBiotic Urinary Care is an evidence-based formula to help reduce the adherance of pathogenic bacteria and promote a healthy urogenital tract. Cranberry contains strong antioxidant proanthocyanidins (PACs) that are active against E. coli, helping to reduce the frequency of recurrent cystitis.

According to a 2012 Cochrane review, cranberry must be standardised to at least 36mg proanthocyanidins daily in divided doses to effectively reduce the adherence of E. coli to the urinary epithelium and reduce the frequency of UTIs.[2] Divided dosing maintains a stronger urinary concentration of PACs over a longer period, enabling the PACs to maintain their ability to reduce the adhesion of E. coli to the urinary epithelium over 24 hours (figure 2b).

Lactobacilli
L. plantarum competitively inhibits the proliferation of pathogens in the urogenital and intestinal tracts, allowing good bacteria to flourish.[3] Lactobacilli produce lactic acid, creating an acidic environment in the urogenital tract. Through the creation of an acidic environment, along with competitive inhibition at the D-mannose receptor (figure 2b), they may help to deter the adherence of pathogenic bacteria to the urogenital epithelium. Lactobacilli may also assist in the maintenance of healthy vaginal flora.

Lactobacillus plantarum and ellagic acid
L. plantarum works to liberate ellagic acid found in pomegranate by helping to cleave and break the bonds of indigestable ellagitannin complexes with its tannase activity (figure 1).[4] This frees up the antioxidant ellagic acid, helping it to reduce the ability of urinary E. coli to reproduce by impacting on its DNA replication (figure 2d).[5]

Vitamin D
Vitamin D3 stimulates innate cathelicidin production in the urinary epithelium when exposed to pathogenic bacteria (figure 2c). Cathelicidin is a potent endogenous antimicrobial, used as a first-line defence by the body.[6]

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  • The active ingredients contained in this product have not been shown to be contraindicated during pregnancy or lactation.
  • Evidence supports the use of cranberry for urinary tract infections. Its safety profile suggests it is appropriate for use during pregnancy. [7]
  • Mild, temporary gastrointestinal disturbances, such as increased flatulence, may occur with probiotic amounts exceeding one billion live organisms. If this occurs reduce the dose, then gradually increase it over time.
  • It is recommended to take probiotics at least four hours away from antibiotics to limit a potential reduction in probiotic effectiveness.[8]
  • If symptoms of UTI become more severe while cranberry is being administered, other treatments may be required and medical advice is recommended.

[1] Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res 2007;51:732-737.
[2] Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database for System Reviews 2012, issue 10.
[3] Gross G, Snel J, Boekhorst MA, et al. Biodiversity of mannose-specific adhesion in Lactobacillus plantarum revisited: strain-specific domain composition of the mannose-adhesin. Beneficial Microbes 2010;1(1):61-66.
[4] Osawa R, Kuroiso K, Goto S, et al. Isolation of tannin-degrading Lactobacilli from humans and fermented foods. Appl Environ Microbiol 2000;66(7):3093-3097.
[5] Weidner-Wells MA, Altom J, Fernandez J, et al. DNA gyrase inhibitory activity of ellagic and derivatives. Bioorg Med Chem Lett 1998;8:97-100.
[6] Zasloff M. Antimicrobia peptides, innate immunity, and the normally sterile urinary tract. J Am Soc Nephrol 2007;18:2810-2816.
[7] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.
[8] Hawrelak JA. Probiotics. In: Pizzorno JE, Murray MT (Eds), Textbook of natural medicine, 3rd ed (pp.1195-1215). St Louis: Churchill Livingstone Elsevier, 2006.