BioCeuticals Ultra Muscleze® various flavours and sizes
BioCeuticals Ultra Muscleze® various flavours and sizes
This is BioCeuticals best selling product, as it is widely used by practitioners in Australia. Ultra Muscleze® is a good-tasting, high dose magnesium powder featuring UltraMag®, a specialised mineral delivery system that enhances absorption and intestinal tolerance of magnesium. Ultra Muscleze® also contains the amino acids carnitine, glutamine and taurine, with malic acid, B vitamins and other supportive nutrients that normalize muscle contractions, and support energy production by the Krebs cycle.
Magnesium deficiency is common (intake is usually 200mg, while RDA is 300mg) and magnesium is excreted faster when stressed. Symptoms of Magnesium deficiency include: anxiety, irritability, insomnia, PMS, hyperactivity, poor regulation of blood glucose levels, muscle spasms and twitching, arrhythmias, palpitations, excessive perspiration, and fatigue.- UltraMag® is a proprietary BioCeuticals® blend of highly bioavailable magnesium chelates.
Supplies important cofactors to support the actions of magnesium, including malic acid, taurine, glutamine, carnitine and a range of B vitamins, especially B6.
UltraMag® is a specialised blend of amino acid chelates that has been formulated to enhance magnesium absorption and intestinal tolerance. When chelated to an amino acid, magnesium is absorbed as an amino acid rather than as a mineral ion. UltraMag® magnesium amino acid chelates are readily absorbed through the intestinal lining via the dipeptide transport pathway. This mechanism of absorption is faster, more efficient and is not dependent upon stomach acidity. Even in individuals with known malabsorption, absorption of UltraMag® has been shown to be substantially greater than that of inorganic magnesium salts (23.5% vs 11.8%) and is better tolerated.
How magnesium's cofactors function in the body
Several B group vitamins are essential to the respiratory chain involved in ATP synthesis. A range of nutrients, including numerous B vitamins, may assist in minimising the systemic effects of stress.
Magnesium and taurine are involved in the modulation of cellular calcium levels; supplementation has been used successfully in deficient patients in the management of muscle cramps.[4,5]
Glutamine exerts an anabolic effect on skeletal muscle by stimulating the synthesis of protein and inhibiting its degradation, thereby promoting muscle growth and repair.
Carnitine is a cofactor necessary for the transport of long-chain fatty acids into the mitochondrial matrix where they undergo oxidation for cellular energy production. Mitochondrial fatty acid oxidation is the primary fuel source in the heart and skeletal muscle.
Clinical applications of magnesium
- To support a healthy cardiovascular system
- To help maintain healthy glucose metabolism
- To support healthy cellular energy production
- To assist muscular cramps and spasms
- To help relieve symptoms of dysmenorrhoea
- To help relieve pregnancy-induced leg cramps
- To help reduce the frequency of migraine headaches
- To assist with nervous tension
- To assist with stress
- To support a healthy immune system
- To help maintain bone health
Cardiovascular health: Magnesium has been referred to as ‘nature’s physiological calcium channel blocker’. Through its role in ion transport systems, magnesium affects not only intracellular calcium levels, but also sodium and potassium levels, resulting in an influence on the conduction of nerve impulses, muscle contraction and the normal rhythm of the healthy heart.[8,9]
Glucose metabolism: Increasing evidence suggests that intracellular magnesium plays a key role in modulating insulin activity and insulin-mediated glucose uptake.
Muscular cramps and spasms: Adequate magnesium levels are required at neuromuscular junctions to permit muscles to relax. The current research supports the use of magnesium in muscle cramps, including pregnancy-related leg cramps.[11-13]
Dysmenorrhoea: A Cochrane review found that magnesium was more effective than placebo for the symptomatic relief of pain in dysmenorrhoea, and the need for additional medication was less.
Migraines: Magnesium concentration has an effect on serotonin receptors, nitric oxide synthesis and release, inflammatory mediators, and a variety of other migraine-related receptors and neurotransmitters.
Stress: Stress hormones, including catecholamines (adrenaline and noradrenaline) and corticosteroids (e.g. cortisol), can promote a reduction in tissue magnesium levels, increase its excretion in the urine, and deplete body stores.[16,17]
Immunity: Dietary magnesium has an effect on inflammation, apoptosis and alterations in the number and function of non-specific immune cell populations.
Bone health: Magnesium supports healthy bone formation and maintenance. Numerous population studies demonstrate a positive association between magnesium intake and bone mineral density. Conversely, magnesium deficiency is associated with hypocalcaemia, as well as vitamin D abnormalities.
Magnesium's widespread influence within the body
For adults, mix one 5g dose (1 scoop) into 100-200mL of water or juice. Consume once or twice daily, or as directed by your healthcare practitioner.
- The active ingredients contained in this product have not been shown to be contraindicated during pregnancy or lactation.
- Magnesium taken in high doses may cause loose stools.
- The product contains selenium which is toxic at high doses. A daily dose of 150 micrograms for adults of selenium from dietary supplements should not be exceeded. This product contains pyridoxine hydrochloride which may be dangerous when used in large amounts or for a long time. If fluid retention persists, seek medical advice. If symptoms persist contact your healthcare practitioner. Vitamin supplement should not replace a balanced diet.
 Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. J Parenter Enteral Nutr 1994;18(5):430-435.
 Abraham GE, Flechas JD. Management of fibromyalgia: rationale for the use of magnesium and malic acid. J Nutr Med 1992;3:49-59.
 Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev 1999;4(4):249-265.
 Taurine monograph. Altern Med Rev 2001;6(1):78-82.
 Yamamoto S, Ohmoto K, Ideguchi S, et al. [Painful muscle cramps in liver cirrhosis and effects of oral taurine administration]. Nippon Shokakibyo Gakkai Zasshi 1994;91(7):1205-1209.
 Kelly GS. Sports nutrition: a review of selected nutritional supplements for bodybuilders and strength athletes. Altern Med Rev 1997;2(3):184-201.
 Kelly GS. L-Carnitine: therapeutic applications of a conditionally-essential amino acid. Altern Med Rev 1998;3(5):345-360.
 Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy of Sciences, 2007.
 Magnesium. Micronutrient information center, Linus Pauling Institute 2014. Viewed 20 May, http://lpi.oregonstate.edu/infocenter/minerals/magnesium/index.html
 Barbagallo M, Dominquez LJ, Galioto A, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003;24(1-3):39-52.
 Roffe C, Sills S, Crome P, et al. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit 2002;8(5):CR326-CR330.
 Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1996;175(1):233-234.
 Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev 2002;(1):CD000121.
 Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2001;(3):CD002119.
 Sinclair S. Migraine headaches: nutritional, botanical and other alternative approaches. Altern Med Rev 1999;4(2):86-95.
 Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 2000;5(2):97-108.
 Galland L. Magnesium, stress and neuropsychiatric disorders. Magnes Trace Elem 1991-1992;10(2-4):287-301.
 Tam M, Gómez S, González-Gross M, et al. Possible roles of magnesium on the immune system. Eur J Clin Nutr 2003;57(10):1193-1197.
 Ilich JZ, Kerstetter JE. Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr 2000;19(6):715-737.