BioCeuticals Ultra Muscleze® P5P (60 tablets)

Bioceuticals_Ultra_Muscleze_p5p.png
BioCeuticals Ultra Muscleze® P5P (60 tablets) - supplement facts.JPG
Bioceuticals_Ultra_Muscleze_p5p.png
BioCeuticals Ultra Muscleze® P5P (60 tablets) - supplement facts.JPG

BioCeuticals Ultra Muscleze® P5P (60 tablets)

0.00

Ultra Muscleze P5P is a combination of 150mg elemental magnesium and 50mg active B6.

Add To Cart

Magnesium's widespread influence within the body

UM_night_diagram.jpg

Magnesium amino acid chelate
Magnesium is an essential mineral in human health. It is involved in over 300 biological functions including energy production, nucleic acid and protein synthesis, electrolyte balance, regulation of muscle contraction and relaxation, nerve conduction, and regulation of vascular tone.[1,2]

Magnesium supports healthy nervous system function, and provides nutritional support for metabolism of carbohydrates, fats and proteins, and cellular energy production.

Pyridoxal-5-phosphate – active B6
Pyridoxal-5-phosphate (P5P), the active coenzyme form of vitamin B6, is the most common form found in human tissue. It is required by about 100 enzymes that are involved in many aspects of human metabolism. These reactions include the synthesis of neurotransmitters, formation of haem, niacin synthesis from tryptophan, nucleic acid production, lipid and carbohydrate metabolism, and steroid hormone formation.[2-4]

P5P is the main circulating form of vitamin B6 exported from the liver, and is the only form that can be used by the enzymes. Therefore, supplementing with P5P bypasses liver conversion to be used in biochemical processes in the active form.[5]

  • The individual ingredients contained in this product have not been shown to be contraindicated during pregnancy or lactation.
  • Magnesium taken in high doses may cause loose stools.
  • Caution is required in individuals with renal impairment as they may be at a higher risk of adverse effects from excess magnesium supplementation.[1]
  • Excess magnesium may cause diarrhoea. 
  • Magnesium is contraindicated in patients with renal failure or heart block (unless a pacemaker is present).[6]
  • Individuals with myasthenia gravis should avoid the use of magnesium supplements.[7,8]
  • Concurrent use of magnesium with fluoroquinolone antibiotics may reduce the absorption of the medication, while tetracycline antibiotics may form insoluble complexes with magnesium when taken together. Take medications either two hours before or four hours after oral magnesium intake.[6,9]
  • Concomitant use of magnesium with calcium channel blockers or anti-arrhythmic medications may potentiate hypotensive or anti-arrhythmic activity. Monitor patient.[6,9]
  • Use of aminoglycoside antibiotics, loop diuretics or thiazide diuretics may increase magnesium requirements due to inhibited absorption or increased loss.[6]
  • Medications which may affect endogenous vitamin B6 levels include antibiotics, hydralazine, isoniazid, oral contraceptives, penicillamine, L-dopa and theophylline.[6]
  • Concurrent use of vitamin B6 with anticonvulsants phenobarbital or phenytoin may decrease efficacy of the medications.[6]

[1] Magnesium. Micronutrient information center. Linus Pauling Institute. Viewed 15 May 2013, http://lpi.oregonstate.edu/infocenter/minerals/magnesium/
[2] Stipanuk MH. Biochemical, physiological, and molecular aspects of human nutrition. St Louis: Saunders Elsevier, 2006.
[3] Vitamin B6. Micronutrient information center. Linus Pauling Institute. Viewed 15 May 2013, http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB6/
[4] Vitamin B6. Nutrient reference values. NHMRC. Viewed 17 May 2013, http://www.nrv.gov.au/nutrients/vitamin%20b6.htm
[5] Monograph vitamin B6 (pyridoxine;pyridoxal 5’-phosphate). Alternative Medicine Review 2001;6(1):87-92.
[6] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010. 
[7] Kaeser HE. Drug-induced myasthenic syndromes. Acta Neurol Scand Suppl 1984;100:39-47. 
[8] Bashuk RG, Krendel DA. Myasthenia gravis presenting as weakness after magnesium administration. Muscle Nerve 1990;13(8):708-712. 
[9] Magnesium. Natural medicines comprehensive database 2013. Viewed 12 May 2013, www.naturaldatabase.com