BioCeuticals UltraBiotic 45

BioCeuticals UltraBiotic 45 (60 capsules) - supplement facts.JPG
BioCeuticals UltraBiotic 45 (60 capsules) - supplement facts.JPG

BioCeuticals UltraBiotic 45


UltraBiotic 45 is a dairy-free blend of 10 probiotic strains delivering 45 billion beneficial organisms to provide nutritional support for the maintenance of healthy intestinal and urogenital flora.


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UltraBiotic 45 strain selection criteria

In formulating UltraBiotic 45, probiotic strains were selected for their natural gastric resistance, bile tolerance and enzymatic activity. Furthermore, each strain has demonstrated health benefits in at least one of the following areas: 

  •        digestive health and function 
  •        immune health and function 
  •        urogenital health and function 
  •        management of medically diagnosed IBS
  •        temporary relief of diarrhoea.

Urogenital health
In the urogenital tract, lactobacilli species, such as L. rhamnosus, help to maintain a healthy bacterial environment by reducing the overgrowth of less desirable species. 

They do this by:[2]

  •        the production of lactic acid and maintenance of an acidic pH
  •        the production of natural antibiotic substances and peroxides
  •        competition with other bacteria through the utilisation of glucose
  •        interference with pathogenic bacteria adherence. 

Many infectious agents cause diarrhoea: rotavirus (most common); adenoviruses; enteroviruses; parasites; and bacterial pathogens such as Escherichia coli, Salmonella and Shigella. 

Probiotics help to relieve symptoms of diarrhoea by:[3] 

  •        competing with pathogens for nutrients and binding sites
  •        increasing the acidity of the intestinal environment
  •        producing a variety of chemicals that kill and inhibit pathogen growth
  •        increasing specific and non-specific immune responses.

When to take probiotics
Probiotics should be taken with food. This is because the pH of an empty stomach is somewhere between 1.8 and 2.6; when you eat, the presence of food has a neutralising effect, increasing the pH to between 3.5 and 4.2, meaning it is nearly 100 times less acidic. Probiotic bacteria are much more likely to survive in this less acidic environment where they remain for approximately two hours awaiting movement into the small intestine.

The probiotic strains in UltraBiotic 45 are tested to ensure they can withstand the pH of the stomach when food is present. Most living organisms cannot survive a pH as low as 1.8; this is why there is very minimal colonisation within the stomach. Only extremely robust strains such as Helicobacter pylori will survive such acidic environments.

Key Benefits:  L. fermentum  andL. rhamnosus are associated with the protective  maintenance of healthy urogenital and gut flora.

With 25 billion L. rhamnosisand L. casei cells, this product has truly excellent general immune support properties.L. casei has been found to diminish IgEmediated, acute-type atopic conditions when taken as a longer course, along with avoidance of the allergenic foods (Kalliomäki et al., 2001), while L. plantarumachieves this in studies of mice (Park et al., 2008).

Breastfeeding mothers may provide similar allergy-reducing assistance to their infants when taking potent probiotic products, according to research onL. casei reported in  The Lancet.“The frequency of atopic  eczema in the probiotic group was half that of the placebo group (15/64 [23%] vs 31/68 [46%]; relative risk 0.51 [95% CI 0.32-0.84]). The number needed to treat was 4.5 (billion) (95% CI 2.6-15.6)” (Kalliomäki et al., 2001)

Thus, gut flora seem to be a source of natural immuno-modulators, and their  removal by antibiotics may account for much of the epidemic of allergy and asthma (Alm et al., 1999; Farooqi & Hopkin 1998).

Recommended Dosage:

Take 1 to 2 capsules daily or as directed by the healthcare practitioner.

  • If diarrhoea persists for more than 6 hours in infants under 6 months, 12 hours in children under 3 years, 24 hours in children aged 3-6 years or 48 hours in adults and children over 6 years, seek medical advice.
  • Not to be used in children under two years of age without medical advice.
  • Mild, temporary gastrointestinal disturbances, such as increased flatulence, may occur with amounts exceeding one billion live organisms. If this occurs reduce the dose, then gradually increase it over time. 
  • It is recommended to take probiotics at least four hours away from antibiotics to limit a potential reduction in probiotic effectiveness.[1]


Alm, J.S., et al., 1999. Atopy in children of families with an anthroposophic lifestyle. Lancet, 353(9163), 1485-1488. PMID: 10232315

Farooqi, I.S. & Hopkin, J.M., 1998. Early childhood infection and atopic disorder. Thorax, 53(11), 927-932. PMID: 10193389

Kalliomäki, M., et al., 2001. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet, 357(9262), 1076-1079. PMID: 11297958

Park, C.W., et al., 2008. New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. Journal of Medicinal Food, 11(3), 405-412. PMID: 18800885

[1] Hawrelak JA. Probiotics. In: Pizzorno JE, Murray MT (Eds), Textbook of natural medicine, 3rd ed (pp.1195-1215). St Louis: Churchill Livingstone Elsevier, 2006.
[2] Hudson T, Reilly P. Vaginitis and vulvovaginitis. In: Pizzorno JE Jr, Murray MT (Eds), Textbook of natural medicine, 3rd ed. (pp.2155-2165). St Louis: Churchill Livingstone Elsevier, 2006. 
[3] Allen SJ, Okoko B, Martinez E, et al. Probiotics for treating infectious diarrhoea. The Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD003048.pub2. DOI: 10.1002/14651858.CD003048.pub2. 
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