BioCeuticals D3 Drops Forte 1000IU per drop (20ml)
BioCeuticals D3 Drops Forte 1000IU per drop (20ml)
Are you concerned about low Vitamin D levels? BioCeuticals D3 Drops Forte is the easy to take patented Vitamin D liquid emulsion, providing a high dose of vanillla-flavoured vitamin D in every delicious drop.
A pleiotropic vitamin
Vitamin D3 is pleiotropic, meaning it influences the expression of numerous genes throughout the body. Once metabolised to its active form 1,25(OH)2D, it binds to the vitamin D receptor (VDR), a transcription factor which, when activated, induces the vitamin D responsive genes distributed in many tissues throughout the body.
Bone development and health
The major function of vitamin D is to maintain serum calcium concentrations within an acceptable range. Inadequate vitamin D levels contribute to low serum calcium, which in turn stimulates the parathyroid glands to increase the production and secretion of parathyroid hormone (PTH). This results in upregulation of osteoclast activity which causes calcium and phosphorus to be released from bone into the blood. Intestinal absorption of calcium and reabsorption of calcium by the kidneys is also increased.[3,4]
Fall reduction in the elderly
A meta-analysis of five randomised controlled trials found that vitamin D may reduce the risk of falls in older people by 20%. Another study found that supplemental vitamin D3 (800IU colecalciferol daily for 12 weeks) in addition to calcium carbonate (1200mg daily) reduced the rate of falls by 60% compared to calcium supplementation alone. These results were partly explained by a change in postural and dynamic balance.[6,7]
Elevated PTH, as seen in vitamin D deficiency, is associated with increased protein catabolism, reduced number of type 2 muscle fibres, reduced mitochondrial oxygen uptake, and impaired oxidation of long-chain fatty acids in skeletal muscle.
Clinically, the vitamin D deficiency may manifest as muscle weakness and bone aches. In a cross-sectional study of 150 patients (male and female aged 10-65 years) who presented with non-specific muscle and bone aches and pains, 93% were found to be vitamin D deficient.
1,25(OH) 2D has been shown to have several effects on heart cell growth and differentiation as well as enhancing calcium transport across the plasma membrane. Vitamin D deficiency has long been known to affect cardiac contractility, vascular tone, cardiac collagen content and tissue maturation.
The renin-angiotensin system (RAS) plays a central role in the regulation of blood pressure, volume and electrolyte homeostasis.
Research has shown that 1,25(OH) 2D administration suppresses renin production through a VDR-mediated mechanism unrelated to changes in serum calcium.
VDRs are present in the healthy prostate where they are involved in healthy prostate cell metabolism, differentiation and maturation. Prostate cells are also able to produce active 1,25(OH)2D and hence are able to regulate their own growth.[15,16]
1,25(OH)2D is considered an immune system modulator with VDRs expressed by most cells of the immune system including T and B cells, natural killer cells, and antigen-presenting cells such as dendritic cells and macrophages.[4,17]
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 Bischoff-Ferrari HA, Dawson-Hughes B, Willett CW, et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004;291(16):1999-2006.
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 Vitamin D levels in children around the world. Vitamin D Council 2013. Viewed 20 May 2014, http://www.vitamindcouncil.org/blog/vitamin-d-levels-in-children-around-the-world/