BioCeuticals D3 Drops Forte 1000IU per drop (20ml)

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BioCeuticals D3 Drops Forte 1000IU per drop (20ml) - supplement facts.JPG
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BioCeuticals D3 Drops Forte 1000IU per drop (20ml) - supplement facts.JPG

BioCeuticals D3 Drops Forte 1000IU per drop (20ml)

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Are you concerned about low Vitamin D levels? BioCeuticals D3 Drops Forte is the easy to take patented Vitamin D liquid emulsion, providing a high dose of vanillla-flavoured vitamin D in every delicious drop. 

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A pleiotropic vitamin 
Vitamin D3 is pleiotropic, meaning it influences the expression of numerous genes throughout the body. Once metabolised to its active form 1,25(OH)2D, it binds to the vitamin D receptor (VDR), a transcription factor which, when activated, induces the vitamin D responsive genes distributed in many tissues throughout the body.[3]

Bone development and health 
The major function of vitamin D is to maintain serum calcium concentrations within an acceptable range. Inadequate vitamin D levels contribute to low serum calcium, which in turn stimulates the parathyroid glands to increase the production and secretion of parathyroid hormone (PTH). This results in upregulation of osteoclast activity which causes calcium and phosphorus to be released from bone into the blood. Intestinal absorption of calcium and reabsorption of calcium by the kidneys is also increased.[3,4]

Fall reduction in the elderly 
A meta-analysis of five randomised controlled trials found that vitamin D may reduce the risk of falls in older people by 20%.[5] Another study found that supplemental vitamin D3 (800IU colecalciferol daily for 12 weeks) in addition to calcium carbonate (1200mg daily) reduced the rate of falls by 60% compared to calcium supplementation alone. These results were partly explained by a change in postural and dynamic balance.[6,7]

Musculoskeletal health 
Elevated PTH, as seen in vitamin D deficiency, is associated with increased protein catabolism, reduced number of type 2 muscle fibres, reduced mitochondrial oxygen uptake, and impaired oxidation of long-chain fatty acids in skeletal muscle.[8]

Clinically, the vitamin D deficiency may manifest as muscle weakness and bone aches.[9] In a cross-sectional study of 150 patients (male and female aged 10-65 years) who presented with non-specific muscle and bone aches and pains, 93% were found to be vitamin D deficient.[10]

Cardiovascular health 
1,25(OH) 2D has been shown to have several effects on heart cell growth and differentiation as well as enhancing calcium transport across the plasma membrane.[11] Vitamin D deficiency has long been known to affect cardiac contractility, vascular tone, cardiac collagen content and tissue maturation.[12]

Renin-angiotensin system 
The renin-angiotensin system (RAS) plays a central role in the regulation of blood pressure, volume and electrolyte homeostasis.[13]

Research has shown that 1,25(OH) 2D administration suppresses renin production through a VDR-mediated mechanism unrelated to changes in serum calcium.[14] 

Prostate health 
VDRs are present in the healthy prostate where they are involved in healthy prostate cell metabolism, differentiation and maturation. Prostate cells are also able to produce active 1,25(OH)2D and hence are able to regulate their own growth.[15,16] 

Immunity 
1,25(OH)2D is considered an immune system modulator with VDRs expressed by most cells of the immune system including T and B cells, natural killer cells, and antigen-presenting cells such as dendritic cells and macrophages.[4,17]

[1] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.
[2] Vitamin D. Natural Medicine Comprehensive Database 2014. Viewed 20 May 2014, www.naturaldatabase.com
[3] Higdon J. Vitamin D. Micronutrient information center, Linus Pauling Institute 2011. Viewed 20 May 2014, http://lpi.oregonstate.edu/infocenter/vitamins/vitaminD/
[4] Tortora GJ, Grabowski SR. Principles of anatomy and physiology, 10th ed. New York: John Wiley & Sons, 2003.
[5] Bischoff-Ferrari HA, Dawson-Hughes B, Willett CW, et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004;291(16):1999-2006.
[6] Bischoff-Ferrari HA, Conzelmann M, Stähelin HB, et al. Is fall prevention by vitamin D mediated by a change in postural or dynamic balance? Osteoporos Int 2006;17(5):656-663. 
[7] Dhesi JK, Jackson SH, Bearne LM, et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 2004;33(6):589-595.
[8] Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int 2002;13(3):187-194.
[9] Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80(6 Suppl):S1678-S1688.
[10] Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003;78(12):1463-1470.
[11] Luong KV, Nguyen LT. Vitamin D and cardiovascular disease. Curr Med Chem 2006;13(20):2443-2447.
[12] Achinger SG, Ayus JC. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int Suppl 2005;(95):S37-S42.
[13] Li YC, Qiao G, Uskokovic M, et al. Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure. J Steroid Biochem Mol Biol 2004;89-90(1-5):387-392.
[14] Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005;289(1):F8-F28.
[15] Birt DF, Shull JD, Yaktine AL. Chemoprevention of cancer. In: Shils ME, Olson JA, Shike M, et al (Eds). Modern nutrition in health and disease, 9th ed (pp. 1263-1295). Philadephia: Lippincott Williams & Wilkins, 1999.
[16] Holick MF. Evolution and function of vitamin D. Recent Results Cancer Res 2003;164:3-28.
[17] Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 2005;26(5):662-687
[18] Vitamin D levels in children around the world. Vitamin D Council 2013. Viewed 20 May 2014, http://www.vitamindcouncil.org/blog/vitamin-d-levels-in-children-around-the-world/