Innate Response Adrenal Response Complete Care (90 tablets)

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Innate Response Adrenal Response Complete Care (90 tablets)

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Non-Glandular Adaptogenic Support from Botanicals

Adrenal Response® Complete Care is a formula with nutrients, herbs, and whole foods to assist the adrenal glands' healthy response to stress.

 

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Ample evidence suggests that eating a typical modern diet, which often consists of excess sugars and carbohydrates, presents significant challenges to optimal wellness. Coupled with the effects of chronic stress, this can lead to poor adrenal function and a cascade of physiological effects in the body ranging from gastrointestinal issues to chronic fatigue and inflammation.[1],[2],[3] We now know that even lower levels of stress, when regularly occurring, can induce a similar detrimental effect in the body as strenuous athletic overtraining.[4] When our bodies feel under threat, the HPA Axis, which regulates our physical reaction to stress over adjusts and triggers elevated cortisol levels. In a recent study, it was discovered that these elevated levels can overtime can lead to a suppressed immune system, and induce glycogenolysis, and insulin resistance.[5] Without proactive treatment and support, these issues may eventually require aggressive strategies to correct. In addition to dietary changes and adopting stress management techniques, ongoing maintenance of the adrenal system is recommended.

The primary inclusion is Sensoril®, derived from the Indian herb ashwaganda. The major constituents of Sensoril®'s anti-stress properties are based upon steroidal lactones called withanolides, which are similar to the body's own steroidal hormones. These active constituents exert their anti-stress and adaptogenic activity by returning the circulating ACTH and concurrent increase in blood corticosterone levels to normal after a stress event. In chronically-stressed patients, Sensoril® has been shown to decrease serum cortisol by 14.5%, while increasing DHEA significantly (by 13.2%) over a two-month period (Auddy et al., 2008).

Sensoril® has also been shown to reduce the activity of the adenosine triphosphatase enzyme (ATPase) in liver mitochondria. As the ATPase enzyme is responsible for the breakdown of ATP, Sensoril® may have a direct and positive effect on energy stores and vitality levels in the body — an effect seen in tratitional medicine. 

Sensoril® Ashwagandha is a clinically researched extract of Withania somnifera and the only form of Ashwagandha that is standardized to 8% withanolides. A 2008 multiphase, double- blind placebo controlled human clinical trial validated its ability to reduce experiential feelings of stress and anxiety, decrease serum cortisol and C-reactive protein levels, and increase serum DHEA levels in a dose-dependent manner.[6] Subjects given the highest dose of 250 mg of Sensoril also saw added support for cardiac health and maintenance of healthy glucose response.

Additional Adaptogenic herbs:

Holy Basil (Ocimum sanctum) is a plant revered in the Ayurvedic tradition for its support of the stress response. Also known as Tulsi, it is backed by current research including a 2014 study showing that it addresses physical, chemical, metabolic and psychological stress through unique pharmacological actions. [7]

Tulsi protects organs and tissues from chemical stress found in industrial pollutants and heavy metals, and supports a healthy response to physical stress from prolonged physical exertion.

Adrenal Response® also contains whole body primary adaptogens Rhodiola and Astragalus offering a synergistic effect that eliminates the need for glandular herbal support.[8] Rhodiola rosea has wide ranging and varied historical uses dating back to the Ancient Greeks. Modern research shows it supports a healthy mood by balancing the parasympathetic nervous system responses and, as an adaptogen, strengthening the body’s response to physical, emotional and mental stress.[9], [10]

Astragalus is considered one of the most important herbs in Chinese medicine. In a 2013 study, it was shown to offer broad protective effects. It is particularly prized for its flavonoids, polysaccharides and triterpene glycosides, which are known to support a healthy immune system.[11] Schisandra berry, is an antioxidant rich fruit that was found in a 2013 study to support energy and stamina levels.[12]

Both formulas are glandular free and Vegetarian Safe:

Tested free of soy, dairy, gluten, herbicides and pesticides, with a formula of adaptogenic herbs, now known to play an important role in adrenal health. Additional Support in Adrenal Response® Complete Care from FoodState Nutrients.

Recommended Dosage:

2 tablets daily, or as directed by the healthcare practitioner.

Sources:

1 A Moshfegh et al. What We Eat in American NHANES 2005-2006, Usual Nutrient Intakes from Food And Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesium, USDA, Agricultural Research Service. http://www.cdc.gov/nchs/nhanes/

2 Berz MD, J. Diet and the Prevention of Chronic Disease. Medscape Public Health, (August 21, 2012) http://www.medscape.com/viewarticle/769218

3 Bhatia V, Tandon RK. Stress and the gastrointestinal tract. J Gastroenterol Hepatol. 2005 Mar;20(3):332-9. Review.

4 Hackney A. Stress and the neuroendocrine system: the role of exercise as a stressor and modifier of stress. Expert Rev Endocrinol Metab. 2006 Nov 1; 1(6): 783–792.

5 Luccassan E, Cizza G. The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity. Curr Obes Rep. 2012 Dec; 1(4): 208–215 Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. JANA, 11(1), 2008: 50-56.

6 JCohen MM. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014 Oct-Dec;5(4):251-9.

7 Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005 Oct;19(10):819-38.

8 Ibid. Phytother Res 2005.

9 EM Olsson et al. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12.

10 A Pannosian. Adaptogens in Mental and Behavioral Disorders, Psychiatric Clinics of North America. 2013 Mar;36(1); 49-64.
11 S. Ren S, et al.. Pharmacological effects of Astragaloside IV: a literature review. J Tradit Chin Med. 2013 Jun;33(3):413-6.
12 Koncic MZ, Tomczyk M. New insights into dietary supplements used in sport: active substances, pharmacological and side effects. Curr Drug Targets. 2013 Aug;14(9):1079-92