Vital Nutrients Curcumin Extract 700mg (with Bioperine®) (60 vegetarian capsules)

24941b56-174f-4ce2-95ea-dc30676daba8-358-358.png
Vital Nutrients Curcumin Extract 700mg (with Bioperine®) (60 vegetarian capsules) - supplement facts.JPG
24941b56-174f-4ce2-95ea-dc30676daba8-358-358.png
Vital Nutrients Curcumin Extract 700mg (with Bioperine®) (60 vegetarian capsules) - supplement facts.JPG

Vital Nutrients Curcumin Extract 700mg (with Bioperine®) (60 vegetarian capsules)

0.00

Curcumin is the principal curcuminoid in turmeric. Curcumin has been reported to have marked anti-inflammatory activity, as outlined in the article "potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases" by (Aggarwal et al, 2009, see also Aggarwal BB, Sung B., 2009).  Owing to hepatic metabolism, little arrives with the circulating plasma even in doses up to 4 grams daily, although it does significantly increase hepatic glutathione levels at lower amounts (Zheng, Yumei & Chen, 2007). Co-supplementation with 20 mg of piperine (extracted from black pepper) significantly increases the absorption of curcumin; one study funded by a prominent manufacturer of piperine claims an increase of 2,000% (Shoba et al., 1998).

 

Add To Cart

In cell culture and animal studies, curcumin has been found to inhibit pro-carcinogen bioactivation caused by Phase I cytochrome P450 activity (Thapliyal & Maru, 2001). At the same time, it increases Phase II enzyme activity, increasing glutathione S-transferases generally thought to enhance the elimination of potential carcinogens (Iqbal et al., 2003).

 

In the colon, curcumin extract has been shown to reduce the oxidative damage to DNA through its cytokyne balancing and antioxidant activities (Iqbal et al., 2003, also Zhou H, et al, 2011)).  Curcumin has also been found to induce cell-cycle arrest and apoptosis in a variety of cancer cell lines grown in culture, including colorectal cancer lines (Garcea et al., 2004; Moos et al., 2004). As a result of the promising findings in animal studies, several controlled clinical trials in humans designed to evaluate the effect of oral curcumin supplementation on precancerous colorectal lesions, such as adenomas, are under way.

 

Recommended Dosage:

1 capsule twice daily, or as directed by the healthcare professional.

If pregnant, consult your physician before taking it.

REFERENCES:

Garcea, G., et al., 2004. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. British Journal of Cancer, 90(5), 1011-1015. PMID: 14997198

 

Iqbal, M., et al., 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacology & Toxicology, 92(1), 33-38. PMID: 12710595

 

Shoba, G. et al., 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353-356. PMID: 9619120

 

Thapliyal, R. & Maru, G.B., 2001. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food and Chemical Toxicology, 39(6), 541-547. PMID: 11346483

 

Zheng, S., Yumei, F. & Chen, A., 2007. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radical Biology and Medicine, 43(3), 444-453. PMID: 17602960

 

Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jul 9.

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.

Aggarwal BB, Harikumar KB.

 

Trends Pharmacol Sci. 2009 Feb;30(2):85-94. doi: 10.1016/j.tips.2008.11.002. Epub 2008 Dec 26.

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.

Aggarwal BB, Sung B.

 

Curr Drug Targets. 2011 Mar 1;12(3):332-47. The targets of curcumin. Zhou H, Beevers CS, Huang S.